Application of solid lipid nanoparticles to improve the. Solid lipid nanoparticles and nanostructured lipid carriers. Slns combine the advantages of lipid emulsion and polymeric nanoparticle systems while overcoming the temporal and in vivo stability issues that troubles the conventional as well as polymeric nanoparticles drug delivery approaches. In this study, formation of submicron stearic acid was reported by using ress process. Basic formulation of sln contained 10% of hydrogenated palm oil softisan 154 and hydrogenated lecithin lipid matrix, 1% oleyl alcohol, 0. Pdf preparation and characterization of solid lipid nanoparticles. The preparation processes have been optimized using experimental design and multiobjective. In vitro drug release profile from sln was studied under various experimental. The ability to incorporate drugs into nanocarriers offers a new method in drug delivery which is used in drug targeting.
Solid lipid nanoparticles a promising drug delivery system. Preparation and physicochemical characterizations of solid. Solid lipid nanoparticles preparation and characterization. International journal of polymeric materials and polymeric biomaterials. Preparation of solid lipid nanoparticles in coflowing. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.
Formulation and characterization of solid lipid nanoparticles loaded neem oil for topical treatment of acne. Solid lipid nanoparticles sln poor drug solubility, poor absorption, drug distribution to nontargeted sites and high fluctuations in drug plasma levels are significant problems in traditional drug delivery systems. A method to prepare solid lipid nanoparticles with improved entrapment efficiency of hydrophilic drugs volume. The particle diameters of the bc loaded nanoparticles with.
Solid lipid nanoparticle, isoniazid, entrapment efficiency, lipid. As the lipids used in the preparation are categorized as gras generally. A method to prepare solid lipid nanoparticles with. Solid lipid nanoparticles are colloidal carrier systems for controlled drug release. Active application number us14775,020 other versions us20160022550a1 en inventor. Sep 19, 2015 solid lipid nanoparticles and nanostructured lipid carriers. Solid lipid nanoparticles are having size 50 nm and are composed of lipid components which are in solid state at room temperature. All the formulations were analyzed for entrapment efficiency by hplc, and the results are shown in table 2. The micrioemulsion based method was adopted for preparation of sln.
Armin braun et al 18, studied the potential cytotoxicity of solid lipid nanoparticles sln for human lung as a suitable drug delivery system dds. In the current study, curcumin was encapsulated in solid lipid nanoparticles slns and nanostructured lipid carriers nlcs for the purpose of increasing brain accumulation. A 32 full factorial experiment was designed to study the effect. The main advantage of slns over liposomes, polymeric nanoparticles and polyester nanoparticles is the lipid matrix which decreases the danger of acute and chronic toxicity and has good tolerability. Overview of preparation methods of polymeric and lipid based niosome, solid lipid, liposome nanoparticles. Development and characterization of solid lipid nanoparticles. A method to prepare solid lipid nanoparticles with improved. Solid lipid nanoparticles slns are prospective carriers for oral delivery of poorly soluble drugs with low bioavailability. Solid lipid nanoparticles slns, prepared using various physiological lipids, emulsifiers and water, have been used since the 1990s as colloidal nanocarrier systems, either in combination with or as an alternative to liposomes, emulsions and polymeric nanoparticles.
Formulation and characterization of rivastigmine loaded. Lipid nanoparticles offer possibility to develop new therapeutics, due to their unique size dependent properties. Solid lipid nanoparticles may be a promising sustained release and drug targeting system for lipophilic cns antitumor drugs 17. This work presents an effective and new method for producing solid lipid nanoparticles slns with small sizes mean diameter less than 250 nm and relatively narrow size distribution polydispersity less than 0. R, plasmid dna, gene delivery, colloidal carriers, preparation, characterization, stability, sln 1. Lipid nanoparticles lnps have attracted special interest during last few decades. Preparation and characterization of rizatriptan loaded. Preparation and characterization of solid lipid nanoparticles loaded with frankincense and myrrh oil feng shi, jihui zhao, ying liu, zhi wang, yongtai zhang, nianping fengschool of pharmacy, shanghai university of traditional chinese medicine, shanghai, peoples republic of chinaabstract. Solid lipid nanoparticles were prepared using glyceryl monostearate by solvent emulsification method followed by probe sonication. Solid lipid nanoparticles it is well known that lipidbased nanoparticles are less toxic and biocompatible compared to inorganic or polymeric nanoparticles 4,5. Proceedings of the asian scientific conference in pharmaceutical technology, june, 2008, singapore, pp. Application of supercritical fluid technology for preparation.
This is one of the most common methods for the preparation of solid lipid nanoparticles 53,5558. Akanksha garud, deepti singh, navneet garud, solid lipid nanoparticles sln. Brain delivery of curcumin using solid lipid nanoparticles. Entrapment efficiency is an important parameter for characterizing solid lipid nanoparticles. Solid lipid nanoparticles are one of the most popular approaches to improve the oral bioavailability of the poorly water soluble drugs. The system consists of spherical solid lipid particles in the nanometer ranges, which are dispersed in water or in aqueous surfactant solution.
Premise of the present study was to suitably select or modify the constitution of the lipid matrix to achieve significantly high entrapment of hydrophilic drugs within solid lipid nanoparticles slns. The preparation process was conducted in a coflowing microchannel assembled with inner and outer capillaries. Therefore, currently, much research on the micronization of stearic acid is going on. Solid lipid nanoparticles and chitosancoated solid lipid nanoparticles as promising tool for silybin delivery. Possessing adjustable release kinetics, determined by the method of preparation used, its. Solid lipid nanoparticles slns comprise a versatile drug delivery. Jul 17, 2009 a method to produce solid lipid nanoparticles sln from wow multiple emulsions was developed applying the solventinwater emulsiondiffusion technique. Apr 08, 2017 types of solid lipid nanoparticles solid lipid nanoparticles can be divided into 3 types on the basis of drug loading. The sln were realised by exchanging the liquid lipid oil of the emulsions by a solid lipid, which means lipids being solid at room temperature but also at body temperature. Solid lipid nanoparticle an overview sciencedirect topics.
Preparation, characterization and evaluation of quetiapine. Preparation and characterization of sildenafil loaded. Overview of preparation methods of polymeric and lipidbased niosome, solid lipid, liposome nanoparticles. Pdf solid lipid nanoparticles and nanostructured lipid. Structure, preparation and application neda naseri, 1 hadi valizadeh, 2 and parvin zakerimilani 3, 1 student research committee and faculty of advanced medical sciences, department of medical nanotechnology, tabriz university of medical sciences, tabriz, iran. Solid lipid nanoparticles slns and nanostructured lipid carriers nlcs are two major types of lipidbased nanoparticles. Different production methods which are suitable for large scale production and applications of solid lipid nanoparticles are described. The synthesis of doxorubicin14squalenate 8 proceeded as. Cationic solid lipid nanoparticles slns were introduced as a nonviral transfection vehicle by olbrich et al. They consist of macromolecular materials in which the active principle drug or biologically active material is dissolved, entrapped, and or to. Solid lipid nanoparticles sln are aqueous colloidal dispersions, the matrix of which comprises of solid biodegradable lipids swathi et al. The particle diameters of the bc loaded nanoparticles with 0.
Formulation, characterization, and in vitro evaluation current drug delivery utilization of a single experimental design for the optimization of furosemide modifiedrelease tablet formulations. Boxbehnken design bbd was applied to optimize the variables affecting the quality of cvd. Hence, solid lipid nanoparticles hold great promise for reaching the goal of controlled and site specific drug delivery and hence have attracted wide attention of researchers. A solid lipid nanoparticles preparation, characterization and production from palm oil. The preparation processes have been optimized using experimental design and multiobjective optimization. Curcumin is a multitherapeutic agent with great therapeutic potential in central nervous system cns diseases. It is identical to an oilinwater emulsion for parenteral nutrition but the liquid lipid oil of the emulsion has been replaced by a solid lipid, i. Present work is an attempt to improve oral bioavailability of quetiapine fumarate by incorporating in solid lipid nanoparticles sln. Nanoparticles, solid lipid nanoparticles, nanosuspension, nanoemulsion, nanocrystals14 classification of nanoparticles. Formulation and characterization of rivastigmine loaded solid. Optimization of carvedilol solid lipid nanoparticles. Overview of preparation methods of polymeric and lipidbased. The influence of process parameters lipid matrix, lipid concentration, carbohydrate type and its concentration on the sln size distribution, zeta potential, entrapment efficiency. Introduction the establishment of gene therapy may be achieved by designing sophisticated gene delivery systems.
Solid lipid nanoparticles sln comprises solid lipid core stabilized by a surfactant at interfacial region. Ultrasonic homogenization method was employed to prepare. Preparation and characterization of candesartan cilexetil. Therefore, the study aimed at developing carvedilol cvd in slns to control its release and enhance its bioavailability in the management of hypertension, and cardiac diseases. Preparation and characterization of solid lipid nanoparticles. Six quetiapine fumarate sln formulations were developed using three different lipids by hot homogenisation followed by ultrasonication. Solid lipid nanoparticles sln, colloidal drug carriers, homogenization, tem, pcs, biodistribution, targeting. The key characteristics of these carriers include a good physical stability, protection of incorporated drugs from. Solid lipid nanoparticle, isoniazid, entrapment efficiency, lipid combination, excipient selection.
Initially used for the production of solid lipid nanoemulsions, this. Preparation and characterization of sildenafil loaded solid. Slns were developed to overcome the limitations of other colloidal carriers, such as emulsions, liposomes and polymeric nanoparticles because they have advantages like good. Preparation and characterization of solid lipid nanoparticles through rapid expansion of supercritical solution zahra akbari1, masoud amanlou 2, javad karimisabet 4, abolfazl golestani 3 and mojtaba shariaty niassar 1 school of chemical engineering, college of engineering, university of tehran 1, tehran, iran. In the present study, we explored the potential of rivastigmine loaded solid lipid nanoparticle sln, as a new formulation in improving the bioavailability of antialzheimer drug rivastigmine which otherwise reported with poor bioavailability. Preparation of solid lipid nanoparticles for ibuprofen delivery. Slns were developed to overcome the limitations of other colloidal carriers, such as emulsions, liposomes and polymeric nanoparticles because they have advantages like good release profile and targeted drug delivery with. The aim of the present study was to prepare solid lipid nanoparticles slns for. Types of solid lipid nanoparticles solid lipid nanoparticles can be divided into 3 types on the basis of drug loading. Correlation between longterm stability of solid lipid nanoparticles sln and crystallinity of the lipid phase. Gamze guney eskiler, gulsah cecener, gokhan dikmen, unal egeli and berrin tunca affiliation. Their benefits as colloidal drug carrier systems, pharmazie 61 2006 375386. Preparation and evaluation lipid nanoparticles of fenofibrate obtained by spray drying technique. A method to produce solid lipid nanoparticles sln from wow multiple emulsions was developed applying the solventinwater emulsiondiffusion technique.
Pdf solid lipid nanoparticles preparation and characterization. Preparation and investigation of solid lipid nanoparticles. Slns were developed to overcome the limitations of other colloidal carriers, such as emulsions, liposomes and polymeric nanoparticles because they have advantages like good release profile. University institute of pharmaceutical sciences, panjab university, chandigarh160014. Lipid nanoparticles ln can be subdivided into two big groups solid lipid nanoparticles sln and nanostructured lipid carriers nlc. Nanoparticles were prepared by the microemulsion or precipitation technique. Preparation of solid lipid nanoparticles from wow emulsions. Solid lipid nanoparticles international current pharmaceutical. The objective of this research was to formulate ciprofloxacin cip in solid lipid nanoparticles slns in an attempt to develop a controlled drug delivery system. From the results obtained, all formulations showed good entrapment efficiency ranging from 82. Deparment of medical biology, faculty of medicine, sakarya university, sakarya, deparment of medical biology, faculty of.
Pdf the presents study aimed to prepare and characterize solid lipid nanoparticles slns from palm oil materials. Solid lipid nanoparticles slns containing total flavones of hippophae rhamnoides tfh were prepared by highpressure homogenization hph, by both hot hph and cold hph. Insulin was chosen as hydrophilic peptide drug to be dissolved in the acidic inner aqueous phase of multiple emulsions and to be consequently carried in sln. If appropriately investigated, solid lipid nanoparticles may open new vistas in therapy of complex diseases. Solid lipid nanoparticles sln for controlled drug delivery production, characterization and sterilization journal of controlled release 30. The reasons for the increasing interest in lipid based system are many fold and include.
Slns were first prepared in the early 1990s by two different methods. The solid lipids are used for the preparation of sln instead of liquid lipids used in case of liposomes to overcome the disadvantages associated with the liquid state and to improve physical stability. An ultrasonic meltemulsification method was used for preparing ciploaded slns. Preparation of solid lipid nanoparticles by a solvent emulsificationdiffusion technique. Overview of preparation methods of polymeric and lipid. The particle size of the mentioned nanocarriers varies from 10 to 800 nm. Solid lipid nanoparticles have recently materialized as a novel approach to oral and parenteral drug delivery systems. Pdf on may 2, 2019, roshan g bodhe and others published preparation and characterization of solid lipid nanoparticles find, read and cite all the research you need on researchgate. Solid lipid nanoparticles slns and nanostructured lipid carriers nlcs are two major types of lipid based nanoparticles.
Preparation, characterization and evaluation of elvitegravir. The number of research groups working in the field slowly but continuously grew from that. Preparation, characterization and evaluation of the therapeutic efficacy in vitro volume. This system called solid lipid nanoparticles sln is defined as drug carrier in the submicron size range made of biocompatible and biodegradable lipids solid at room and body temperature. The main advantage of slns over liposomes, polymeric nanoparticles and polyester nanoparticles is the lipid matrix which decreases the danger of acute and chronic toxicity and has good tolerability 1. Solid lipid nanoparticles and nanostructured lipid. Solid lipid nanoparticles slns, as well as liposomes, dendrimers, and polymeric nanoparticles. Pdf on may 2, 2019, roshan g bodhe and others published preparation and characterization of solid lipid nanoparticles find, read and. Particle size and distribution, ph, viscosity, drug incorporation and zeta potential of the slns. Stearic acid is a good lipid for development of solid lipid nanoparticles slns in drug delivery systems. Pdf preparation of solid lipid nanoparticles for ibuprofen. Boxbehnken design bbd was applied to optimize the variables affecting the quality. Uner, preparation, characterization and physicochemical properties of solid lipid nanoparticles sln and nanostructured lipid carriers nlc. Solid lipid nanoparticles slns are a new pharmaceutical delivery system or pharmaceutical formulation the conventional approaches such as use of permeation enhancers, surface modification, prodrug synthesis, complex formation and colloidal lipid carrier based strategies have been developed for the delivery of drugs to intestinal lymphatics.
All components were weighted into sealed containers and heated to 80 c. Aspects of solid lipid nanoparticles route of administration and their biodistribution are also incorporated. Solid lipid nanoparticles the solid lipid nanoparticles slns are submicron colloidal carriers which are composed of physiological lipid, dispersed in water or in an aqueous surfactant solution. As the lipids used in the preparation are categorized as gras generally recognised as safe substances 1. Solid lipid nanoparticles sln are the rapidly developing field of nanotechnology with many potential applications in drug delivery and research. Slns combine the advantages and avoid the drawbacks of several colloidal carriers of its class such as physical stability, protection of incorporated labile drugs. This work investigated the potential of solid lipid nanoparticles slns to improve oral bioavailablity and tissue uptake of a poorly soluble drug. Particle size and distribution, ph, viscosity, drug incorporation and zeta potential of the slns were investigated.